NCOA4
NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.94).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis.
- 3 · How drugs use it
No product in this corpus aims at NCOA4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7671 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13772 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000266412 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: thyroid cancer 0.54 (GraphQL API, CC0))
Biology
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Another study shows only weak behaviour as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR. Location: Cytoplasmic vesicle, autophagosome; Autolysosome; Nucleus; Chromosome (UniProt). Locus 10q11.22 (HGNC).
- Thyroid cancer: Open Targets association 0.54 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NCOA4" OR ABSTRACT:"NCOA4" OR TITLE:"nuclear receptor coactivator 4" OR ABSTRACT:"nuclear receptor coactivator 4" OR TITLE:"Nuclear receptor coactivator 4" OR ABSTRACT:"Nuclear receptor coactivator 4" OR TITLE:"ARA70" OR ABSTRACT:"ARA70" OR TITLE:"ELE1" OR ABSTRACT:"ELE1" OR TITLE:"PTC3" OR ABSTRACT:"PTC3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOA4, not a curated reading list.
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