TG
TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.95, animal model 0.59, genetic association 0.72, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
- 3 · How drugs use it
No product in this corpus aims at TG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11764 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01266 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000042832 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: thyroid cancer 0.55 (GraphQL API, CC0))
Biology
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Location: Secreted (UniProt). Locus 8q24.22 (HGNC).
- Thyroid cancer: Open Targets association 0.55 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TG" OR ABSTRACT:"TG" OR TITLE:"thyroglobulin" OR ABSTRACT:"thyroglobulin" OR TITLE:"Thyroglobulin" OR ABSTRACT:"Thyroglobulin" OR TITLE:"AITD3" OR ABSTRACT:"AITD3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TG, not a curated reading list.
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