MINPP1
MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.71, somatic mutation 0.55, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates.
- 3 · How drugs use it
No product in this corpus aims at MINPP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7102 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UNW1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107789 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: thyroid cancer 0.62 (GraphQL API, CC0))
Biology
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolysing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of haemoglobin. Location: Endoplasmic reticulum lumen; Secreted; Cell membrane (UniProt). Locus 10q23.2 (HGNC).
- Thyroid cancer: Open Targets association 0.62 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MINPP1" OR ABSTRACT:"MINPP1" OR TITLE:"multiple inositol-polyphosphate phosphatase 1" OR ABSTRACT:"multiple inositol-polyphosphate phosphatase 1" OR TITLE:"Multiple inositol polyphosphate phosphatase 1" OR ABSTRACT:"Multiple inositol polyphosphate phosphatase 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MINPP1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetFOXE1
Shares Thyroid cancer, Open Targets Platform.
- TargetHABP2
Shares Thyroid cancer, Open Targets Platform.
- TargetNCOA4
Shares Thyroid cancer, Open Targets Platform.
- TargetSDCCAG8
Shares Thyroid cancer, Open Targets Platform.
- TargetSRGAP1
Shares Thyroid cancer, Open Targets Platform.
- TargetTG
Shares Thyroid cancer, Open Targets Platform.
- TargetTHRA
Shares Thyroid cancer, Open Targets Platform.
- TargetTHRB
Shares Thyroid cancer, Open Targets Platform.