HABP2
HABP2 (Factor VII-activating protease) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.67, genetic association 0.67, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HABP2 (Factor VII-activating protease) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
HABP2 (Factor VII-activating protease) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly.
- 3 · How drugs use it
No product in this corpus aims at HABP2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:4798 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14520 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000148702 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: thyroid cancer 0.51 (GraphQL API, CC0))
Biology
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumour suppressor negatively regulating cell proliferation and cell migration. Location: Secreted (UniProt). Locus 10q25.3 (HGNC).
- Thyroid cancer: Open Targets association 0.51 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HABP2" OR ABSTRACT:"HABP2" OR TITLE:"hyaluronan binding protein 2" OR ABSTRACT:"hyaluronan binding protein 2" OR TITLE:"Factor VII-activating protease" OR ABSTRACT:"Factor VII-activating protease" OR TITLE:"HGFAL" OR ABSTRACT:"HGFAL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HABP2, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetFOXE1
Shares Thyroid cancer, Open Targets Platform.
- TargetMINPP1
Shares Thyroid cancer, Open Targets Platform.
- TargetNCOA4
Shares Thyroid cancer, Open Targets Platform.
- TargetSDCCAG8
Shares Thyroid cancer, Open Targets Platform.
- TargetSRGAP1
Shares Thyroid cancer, Open Targets Platform.
- TargetTG
Shares Thyroid cancer, Open Targets Platform.
- TargetTHRA
Shares Thyroid cancer, Open Targets Platform.
- TargetTHRB
Shares Thyroid cancer, Open Targets Platform.