SDCCAG8
SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.68, animal model 0.44, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Plays a role in the establishment of cell polarity and epithelial lumen formation.
- 3 · How drugs use it
No product in this corpus aims at SDCCAG8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10671 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86SQ7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000054282 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: thyroid cancer 0.53 (GraphQL API, CC0))
Biology
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body; Cell junction (UniProt). Locus 1q43-q44 (HGNC).
- Thyroid cancer: Open Targets association 0.53 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SDCCAG8" OR ABSTRACT:"SDCCAG8" OR TITLE:"SHH signaling and ciliogenesis regulator SDCCAG8" OR ABSTRACT:"SHH signaling and ciliogenesis regulator SDCCAG8" OR TITLE:"Serologically defined colon cancer antigen 8" OR ABSTRACT:"Serologically defined colon cancer antigen 8" OR TITLE:"NY-CO-8" OR ABSTRACT:"NY-CO-8" OR TITLE:"CCCAP" OR ABSTRACT:"CCCAP" OR TITLE:"SLSN7" OR ABSTRACT:"SLSN7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDCCAG8, not a curated reading list.
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