STRN
STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
Overview
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.91, genetic association 0.51, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
- 1 · What it is
STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
- 2 · What goes wrong in cancer
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.
- 3 · How drugs use it
No product in this corpus aims at STRN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11424 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43815 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115808 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: thyroid cancer 0.54, lung cancer 0.53 (GraphQL API, CC0))
Biology
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Membrane; Cell projection, dendritic spine (UniProt). Locus 2p22.2 (HGNC).
- Thyroid cancer: Open Targets association 0.54 with thyroid cancer (MONDO_0002108)
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"STRN" OR ABSTRACT:"STRN" OR TITLE:"striatin" OR ABSTRACT:"striatin" OR TITLE:"Striatin" OR ABSTRACT:"Striatin" OR TITLE:"PPP2R6A" OR ABSTRACT:"PPP2R6A" OR TITLE:"STRN1" OR ABSTRACT:"STRN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STRN, not a curated reading list.
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