CCDC6
CCDC6 (Coiled-coil domain-containing protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer, Neuroendocrine tumours and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Acts as a structural scaffold that organises free PP2Ac into a configuration that FBXO42 can recognise and ubiquitinate, leading to its proteasomal degradation. Also interacts independently with PPP4C through a mechanism distinct from FBXO42-mediated ubiquitination. Location: Cytoplasm; Cytoplasm, cytoskeleton (UniProt). Locus 10q21.2 (HGNC).
- Lung cancer: Open Targets association 0.72 with lung cancer (MONDO_0008903)
- Thyroid cancer: Open Targets association 0.70 with thyroid cancer (MONDO_0002108)
- Neuroendocrine tumours: Open Targets association 0.63 with neuroendocrine neoplasm (MONDO_0019496)
- Non-small-cell lung cancer: Open Targets association 0.72 with non-small cell lung carcinoma (MONDO_0005233)
- Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CCDC6" OR ABSTRACT:"CCDC6" OR TITLE:"coiled-coil domain containing 6" OR ABSTRACT:"coiled-coil domain containing 6" OR TITLE:"Coiled-coil domain-containing protein 6" OR ABSTRACT:"Coiled-coil domain-containing protein 6" OR TITLE:"H4" OR ABSTRACT:"H4" OR TITLE:"PTC1" OR ABSTRACT:"PTC1" OR TITLE:"TST1" OR ABSTRACT:"TST1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ccdc6.json. Licence CC BY-NC 4.0.