ACSL6
ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
Overview
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Liposarcoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
- 1 · What it is
ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
- 2 · What goes wrong in cancer
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation.
- 3 · How drugs use it
No product in this corpus aims at ACSL6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:16496 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKU0 (protein name, function text, keywords and locations (REST API)); IntOGen ACSL6 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).
- Sarcomas: IntOGen driver in 1 cohort (LIPO)
- Liposarcoma: IntOGen driver in 1 cohort (LIPO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ACSL6" OR ABSTRACT:"ACSL6" OR TITLE:"acyl-CoA synthetase long chain family member 6" OR ABSTRACT:"acyl-CoA synthetase long chain family member 6" OR TITLE:"Long-chain-fatty-acid--CoA ligase 6" OR ABSTRACT:"Long-chain-fatty-acid--CoA ligase 6" OR TITLE:"KIAA0837" OR ABSTRACT:"KIAA0837" OR TITLE:"ACS2" OR ABSTRACT:"ACS2" OR TITLE:"LACS5" OR ABSTRACT:"LACS5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACSL6, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetDDIT3
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Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
- TargetFUS
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- PersonPatrick Schöffski
- TrialSTRASS (EORTC 62092)