DDIT3
DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
Overview
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.97, genetic literature 0.30).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
- 1 · What it is
DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
- 2 · What goes wrong in cancer
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at DDIT3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2726 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0DPQ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000175197 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: sarcoma 0.63, liposarcoma 0.60 (GraphQL API, CC0))
Biology
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.3 (HGNC).
- Sarcomas: Open Targets association 0.63 with sarcoma (MONDO_0005089)
- Liposarcoma: Open Targets association 0.60 with liposarcoma (MONDO_0005060)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DDIT3" OR ABSTRACT:"DDIT3" OR TITLE:"DNA damage inducible transcript 3" OR ABSTRACT:"DNA damage inducible transcript 3" OR TITLE:"DDIT3 upstream open reading frame protein" OR ABSTRACT:"DDIT3 upstream open reading frame protein" OR TITLE:"CHOP10" OR ABSTRACT:"CHOP10" OR TITLE:"GADD153" OR ABSTRACT:"GADD153") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDIT3, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetACSL6
- TargetMB21D2
- TargetFUS
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
- TrialAPG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors
- TechnologyMDM2 inhibitors
- TrialSpearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
- PersonPatrick Schöffski
- TrialSTRASS (EORTC 62092)