ACSL6
ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).
- Sarcomas: IntOGen driver in 1 cohort (LIPO)
- Liposarcoma: IntOGen driver in 1 cohort (LIPO)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ACSL6" OR ABSTRACT:"ACSL6" OR TITLE:"acyl-CoA synthetase long chain family member 6" OR ABSTRACT:"acyl-CoA synthetase long chain family member 6" OR TITLE:"Long-chain-fatty-acid--CoA ligase 6" OR ABSTRACT:"Long-chain-fatty-acid--CoA ligase 6" OR TITLE:"KIAA0837" OR ABSTRACT:"KIAA0837" OR TITLE:"ACS2" OR ABSTRACT:"ACS2" OR TITLE:"LACS5" OR ABSTRACT:"LACS5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACSL6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/acsl6.json. Licence CC BY-NC 4.0.