CEP89
CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Overview
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 1 · What it is
CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
- 3 · How drugs use it
No product in this corpus aims at CEP89 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:25907 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96ST8 (protein name, function text, keywords and locations (REST API)); IntOGen CEP89 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 19q13.11 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CEP89" OR ABSTRACT:"CEP89" OR TITLE:"centrosomal protein 89" OR ABSTRACT:"centrosomal protein 89" OR TITLE:"Centrosomal protein of 89 kDa" OR ABSTRACT:"Centrosomal protein of 89 kDa" OR TITLE:"FLJ14640" OR ABSTRACT:"FLJ14640" OR TITLE:"CCDC123" OR ABSTRACT:"CCDC123") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEP89, not a curated reading list.