PEG3
PEG3 (Paternally-expressed gene 3 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Overview
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PEG3 (Paternally-expressed gene 3 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
- 1 · What it is
PEG3 (Paternally-expressed gene 3 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
- 2 · What goes wrong in cancer
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage.
- 3 · How drugs use it
No product in this corpus aims at PEG3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:8826 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9GZU2 (protein name, function text, keywords and locations (REST API)); IntOGen PEG3 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumour suppressing activity in glioma cells. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.43 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PEG3" OR ABSTRACT:"PEG3" OR TITLE:"paternally expressed 3" OR ABSTRACT:"paternally expressed 3" OR TITLE:"Paternally-expressed gene 3 protein" OR ABSTRACT:"Paternally-expressed gene 3 protein" OR TITLE:"ZKSCAN22" OR ABSTRACT:"ZKSCAN22" OR TITLE:"KIAA0287" OR ABSTRACT:"KIAA0287" OR TITLE:"ZNF904" OR ABSTRACT:"ZNF904") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PEG3, not a curated reading list.