GPC5
GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
Overview
Cell surface proteoglycan that bears heparan sulfate.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.54, somatic mutation 0.43). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cholangiocarcinoma, Ovarian Epithelial Tumour.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
- 1 · What it is
GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
- 2 · What goes wrong in cancer
Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt).
- 3 · How drugs use it
No product in this corpus aims at GPC5 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:4453 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78333 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179399 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0)); IntOGen GPC5 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt). Locus 13q31.3 (HGNC).
- Ovarian cancer: IntOGen driver in 1 cohort (OVT)
- Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GPC5" OR ABSTRACT:"GPC5" OR TITLE:"glypican 5" OR ABSTRACT:"glypican 5" OR TITLE:"Glypican-5" OR ABSTRACT:"Glypican-5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GPC5, not a curated reading list.
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