NT5C3A
NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Overview
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
- 1 · What it is
NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
- 2 · What goes wrong in cancer
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
- 3 · How drugs use it
No product in this corpus aims at NT5C3A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:17820 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H0P0 (protein name, function text, keywords and locations (REST API)); IntOGen NT5C3A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. Location: Cytoplasm; Endoplasmic reticulum (UniProt). Locus 7p14.3 (HGNC).
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NT5C3A" OR ABSTRACT:"NT5C3A" OR TITLE:"5'-nucleotidase, cytosolic IIIA" OR ABSTRACT:"5'-nucleotidase, cytosolic IIIA" OR TITLE:"Cytosolic 5'-nucleotidase 3A" OR ABSTRACT:"Cytosolic 5'-nucleotidase 3A" OR TITLE:"UMPH1" OR ABSTRACT:"UMPH1" OR TITLE:"PSN1" OR ABSTRACT:"PSN1" OR TITLE:"PN-I" OR ABSTRACT:"PN-I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NT5C3A, not a curated reading list.