HSP90AA1
HSP90AA1 (Heat shock protein HSP 90-alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Overview
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes clinical 0.63, affected pathway 0.99, literature 1.00, genetic association 0.00, somatic mutation 0.43, animal model 0.52). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HSP90AA1 (Heat shock protein HSP 90-alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 1 · What it is
HSP90AA1 (Heat shock protein HSP 90-alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
- 3 · How drugs use it
No product in this corpus aims at HSP90AA1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:5253 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07900 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000080824 (association with cancer (MONDO_0004992) 0.75; (GraphQL API, CC0)); IntOGen HSP90AA1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. Location: Nucleus; Cytoplasm; Melanosome; Cell membrane (UniProt). Locus 14q32.31 (HGNC).
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.63; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HSP90AA1" OR ABSTRACT:"HSP90AA1" OR TITLE:"heat shock protein 90 alpha family class A member 1" OR ABSTRACT:"heat shock protein 90 alpha family class A member 1" OR TITLE:"Heat shock protein HSP 90-alpha" OR ABSTRACT:"Heat shock protein HSP 90-alpha" OR TITLE:"Hsp89" OR ABSTRACT:"Hsp89" OR TITLE:"Hsp90" OR ABSTRACT:"Hsp90" OR TITLE:"FLJ31884" OR ABSTRACT:"FLJ31884") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSP90AA1, not a curated reading list.