SDHA
SDHA (Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Renal cell carcinoma, Hepatocellular carcinoma and 5 more.
Overview
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.81, somatic mutation 0.86, genetic literature 0.81). IntOGen calls it a driver in 3 cohorts (2 activating, 0 loss-of-function), covering Chromophobe Renal Cell Carcinoma, Hepatocellular Carcinoma, Low-Grade Glioma, NOS.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDHA (Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Renal cell carcinoma, Hepatocellular carcinoma and 5 more.
- 1 · What it is
SDHA (Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Renal cell carcinoma, Hepatocellular carcinoma and 5 more.
- 2 · What goes wrong in cancer
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- 3 · How drugs use it
No product in this corpus aims at SDHA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:10680 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31040 (protein name, function text, keywords and locations (REST API)); CIViC gene SDHA (1 evidence items, 0 assertions, 2 variants; diseases: Adrenal Gland Pheochromocytoma (GraphQL API, CC0)); Open Targets ENSG00000073578 (association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: colorectal cancer 0.51, ovarian cancer 0.50, sarcoma 0.52, neuroendocrine neoplasm 0.84, gastrointestinal stromal tumour 0.74, lung cancer 0.52 (GraphQL API, CC0)); IntOGen SDHA (driver in 3 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Can act as a tumour suppressor. Location: Mitochondrion inner membrane (UniProt). Locus 5p15.33 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.84 with neuroendocrine neoplasm (MONDO_0019496)
- Renal cell carcinoma: IntOGen driver in 1 cohort (CHRCC)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Sarcomas: Open Targets association 0.52 with sarcoma (MONDO_0005089)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Adrenal Gland Pheochromocytoma; Low-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"SDHA" OR ABSTRACT:"SDHA" OR TITLE:"succinate dehydrogenase complex flavoprotein subunit A" OR ABSTRACT:"succinate dehydrogenase complex flavoprotein subunit A" OR TITLE:"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial" OR TITLE:"SDH2" OR ABSTRACT:"SDH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHA, not a curated reading list.
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