SDHC
SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
Overview
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.91, genetic association 0.43, somatic mutation 0.97, animal model 0.38).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
- 1 · What it is
SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
- 2 · What goes wrong in cancer
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- 3 · How drugs use it
No product in this corpus aims at SDHC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10682 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143252 (association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: colorectal cancer 0.50, neuroendocrine neoplasm 0.83, gastrointestinal stromal tumour 0.72, breast cancer 0.54 (GraphQL API, CC0))
Biology
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1q23.3 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.83 with neuroendocrine neoplasm (MONDO_0019496)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
- Gastrointestinal stromal tumour: Open Targets association 0.72 with gastrointestinal stromal tumour (MONDO_0011719)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SDHC" OR ABSTRACT:"SDHC" OR TITLE:"succinate dehydrogenase complex subunit C" OR ABSTRACT:"succinate dehydrogenase complex subunit C" OR TITLE:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR TITLE:"CYB560" OR ABSTRACT:"CYB560" OR TITLE:"cybL" OR ABSTRACT:"cybL" OR TITLE:"PGL3" OR ABSTRACT:"PGL3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHC, not a curated reading list.
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