SDHB
SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Breast cancer and Gastrointestinal stromal tumour.
Overview
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
CIViC holds 3 clinical evidence items and 0 assertions across 4 variants, naming Vandetanib and Metformin. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.32, genetic association 0.61, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Breast cancer and Gastrointestinal stromal tumour.
- 1 · What it is
SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Breast cancer and Gastrointestinal stromal tumour.
- 2 · What goes wrong in cancer
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- 3 · How drugs use it
No product in this corpus aims at SDHB yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:10681 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21912 (protein name, function text, keywords and locations (REST API)); CIViC gene SDHB (3 evidence items, 0 assertions, 4 variants; diseases: Paraganglioma, Hereditary Renal Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000117118 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.88, gastrointestinal stromal tumour 0.75, breast cancer 0.54 (GraphQL API, CC0))
Biology
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1p36.13 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.88 with neuroendocrine neoplasm (MONDO_0019496)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Gastrointestinal stromal tumour: Open Targets association 0.75 with gastrointestinal stromal tumour (MONDO_0011719)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Paraganglioma; Hereditary Renal Cell Carcinoma.
Latest papers
topQuery for this target: (TITLE:"SDHB" OR ABSTRACT:"SDHB" OR TITLE:"succinate dehydrogenase complex iron sulfur subunit B" OR ABSTRACT:"succinate dehydrogenase complex iron sulfur subunit B" OR TITLE:"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial" OR TITLE:"SDH1" OR ABSTRACT:"SDH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHB, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetSDHC
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
- TargetSDHA
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, CIViC, Open Targets Platform.
- TargetMAX
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
- TargetCHD2
Shares Gastrointestinal stromal tumour (GIST), Open Targets Platform.