DUSP16
DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Overview
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 1 · What it is
DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
- 3 · How drugs use it
No product in this corpus aims at DUSP16 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:17909 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BY84 (protein name, function text, keywords and locations (REST API)); IntOGen DUSP16 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Location: Cytoplasm; Nucleus; Cytoplasmic vesicle (UniProt). Locus 12p13.2 (HGNC).
- Colorectal cancer: IntOGen driver in 2 cohorts (COADREAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DUSP16" OR ABSTRACT:"DUSP16" OR TITLE:"dual specificity phosphatase 16" OR ABSTRACT:"dual specificity phosphatase 16" OR TITLE:"Dual specificity protein phosphatase 16" OR ABSTRACT:"Dual specificity protein phosphatase 16" OR TITLE:"MKP-7" OR ABSTRACT:"MKP-7" OR TITLE:"KIAA1700" OR ABSTRACT:"KIAA1700" OR TITLE:"MKP7" OR ABSTRACT:"MKP7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DUSP16, not a curated reading list.