DCAF12L2
DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
Overview
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2".
IntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Colon Adenocarcinoma, Glioblastoma Multiforme, Lung Adenocarcinoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
- 1 · What it is
DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
- 2 · What goes wrong in cancer
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2". Locus Xq25 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at DCAF12L2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:32950 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VW00 (protein name, function text, keywords and locations (REST API)); IntOGen DCAF12L2 (driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2". Locus Xq25 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COAD)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DCAF12L2" OR ABSTRACT:"DCAF12L2" OR TITLE:"DDB1 and CUL4 associated factor 12 like 2" OR ABSTRACT:"DDB1 and CUL4 associated factor 12 like 2" OR TITLE:"DDB1- and CUL4-associated factor 12-like protein 2" OR ABSTRACT:"DDB1- and CUL4-associated factor 12-like protein 2" OR TITLE:"WDR40C" OR ABSTRACT:"WDR40C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DCAF12L2, not a curated reading list.