PTPN3
PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Overview
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
- 1 · What it is
PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
- 2 · What goes wrong in cancer
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
- 3 · How drugs use it
No product in this corpus aims at PTPN3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:9655 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P26045 (protein name, function text, keywords and locations (REST API)); IntOGen PTPN3 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Location: Cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 9q31.3 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PTPN3" OR ABSTRACT:"PTPN3" OR TITLE:"protein tyrosine phosphatase non-receptor type 3" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 3" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 3" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 3" OR TITLE:"PTPH1" OR ABSTRACT:"PTPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN3, not a curated reading list.