RRN3
RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Overview
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 1 · What it is
RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).
- 3 · How drugs use it
No product in this corpus aims at RRN3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:30346 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYV6 (protein name, function text, keywords and locations (REST API)); IntOGen RRN3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). Location: Nucleus, nucleolus (UniProt). Locus 16p13.11 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RRN3" OR ABSTRACT:"RRN3" OR TITLE:"RNA polymerase I transcription factor RRN3" OR ABSTRACT:"RNA polymerase I transcription factor RRN3" OR TITLE:"RNA polymerase I-specific transcription initiation factor RRN3" OR ABSTRACT:"RNA polymerase I-specific transcription initiation factor RRN3" OR TITLE:"DKFZp566E104" OR ABSTRACT:"DKFZp566E104" OR TITLE:"TIF-IA" OR ABSTRACT:"TIF-IA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RRN3, not a curated reading list.