CAMTA1
CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
Overview
Transcriptional activator.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Leiomyosarcoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
- 1 · What it is
CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
- 2 · What goes wrong in cancer
Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CAMTA1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:18806 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6Y1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171735 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.55, lung cancer 0.51 (GraphQL API, CC0)); IntOGen CAMTA1 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt). Locus 1p36.31-p36.23 (HGNC).
- Sarcomas: IntOGen driver in 1 cohort (LMS)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CAMTA1" OR ABSTRACT:"CAMTA1" OR TITLE:"calmodulin binding transcription activator 1" OR ABSTRACT:"calmodulin binding transcription activator 1" OR TITLE:"Calmodulin-binding transcription activator 1" OR ABSTRACT:"Calmodulin-binding transcription activator 1" OR TITLE:"KIAA0833" OR ABSTRACT:"KIAA0833") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CAMTA1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCLTCL1
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetUSP6
Shares Lung cancer (all types), Skin cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types).
- TargetDDX6
Shares Leiomyosarcoma, Lung cancer (all types), Sarcomas (soft tissue, bone, GIST), IntOGen.
- TargetPIK3CB
Shares Lung cancer (all types), Skin cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types).
- TargetPRDM16
Shares Lung cancer (all types), Skin cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types).
- TargetZBTB16
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetCACNA1D
Shares Lung cancer (all types), Skin cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types).
- TargetAFDN
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.