TRIM33
TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
Overview
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.41, genetic association 0.02, somatic mutation 0.98). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
- 1 · What it is
TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
- 2 · What goes wrong in cancer
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway.
- 3 · How drugs use it
No product in this corpus aims at TRIM33 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:16290 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UPN9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197323 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.50, breast cancer 0.53, lung cancer 0.53 (GraphQL API, CC0)); IntOGen TRIM33 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalling cascade. Plays a role in the control of cell proliferation. Location: Nucleus (UniProt). Locus 1p13.2 (HGNC).
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
- Medulloblastoma: IntOGen driver in 2 cohorts (MBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TRIM33" OR ABSTRACT:"TRIM33" OR TITLE:"tripartite motif containing 33" OR ABSTRACT:"tripartite motif containing 33" OR TITLE:"E3 ubiquitin-protein ligase TRIM33" OR ABSTRACT:"E3 ubiquitin-protein ligase TRIM33" OR TITLE:"TIF1GAMMA" OR ABSTRACT:"TIF1GAMMA" OR TITLE:"FLJ11429" OR ABSTRACT:"FLJ11429" OR TITLE:"KIAA1113" OR ABSTRACT:"KIAA1113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM33, not a curated reading list.
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