HIP1
HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
Overview
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes affected pathway 0.83, literature 0.86, genetic association 0.00, somatic mutation 0.83, animal model 0.62). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Medulloblastoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Upper Tract Urothelial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
- 1 · What it is
HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
- 2 · What goes wrong in cancer
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner.
- 3 · How drugs use it
No product in this corpus aims at HIP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:4913 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00291 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127946 (association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: skin cancer 0.50, breast cancer 0.56, lung cancer 0.53 (GraphQL API, CC0)); IntOGen HIP1 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). Location: Cytoplasm; Nucleus; Endomembrane system; Cytoplasmic vesicle, clathrin-coated vesicle membrane (UniProt). Locus 7q11.23 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)
- Medulloblastoma: IntOGen driver in 1 cohort (MBL)
- Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HIP1" OR ABSTRACT:"HIP1" OR TITLE:"huntingtin interacting protein 1" OR ABSTRACT:"huntingtin interacting protein 1" OR TITLE:"Huntingtin-interacting protein 1" OR ABSTRACT:"Huntingtin-interacting protein 1" OR TITLE:"ILWEQ" OR ABSTRACT:"ILWEQ") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HIP1, not a curated reading list.
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