WNT1
WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
Overview
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
- 1 · What it is
WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
- 2 · What goes wrong in cancer
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation.
- 3 · How drugs use it
No product in this corpus aims at WNT1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:12774 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04628 (protein name, function text, keywords and locations (REST API)); IntOGen WNT1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 12q13.12 (HGNC).
- Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"WNT1" OR ABSTRACT:"WNT1" OR TITLE:"Wnt family member 1" OR ABSTRACT:"Wnt family member 1" OR TITLE:"Proto-oncogene Wnt-1" OR ABSTRACT:"Proto-oncogene Wnt-1" OR TITLE:"INT1" OR ABSTRACT:"INT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WNT1, not a curated reading list.
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