FAM135B
FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
Overview
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B".
IntOGen calls it a driver in 9 cohorts (3 activating, 6 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Well-Differentiated Thyroid Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
- 1 · What it is
FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
- 2 · What goes wrong in cancer
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B". Locus 8q24.23 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at FAM135B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:28029 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q49AJ0 (protein name, function text, keywords and locations (REST API)); IntOGen FAM135B (driver in 9 cohorts (Act 3, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B". Locus 8q24.23 (HGNC).
- Head and neck squamous cell carcinoma: IntOGen driver in 2 cohorts (HNSC)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Endometrial cancer: IntOGen driver in 1 cohort (UCEC)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Non-small-cell lung cancer: IntOGen driver in 3 cohorts (LUSC)
- Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 6 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FAM135B" OR ABSTRACT:"FAM135B" OR TITLE:"family with sequence similarity 135 member B" OR ABSTRACT:"family with sequence similarity 135 member B" OR TITLE:"C8ORFK32" OR ABSTRACT:"C8ORFK32") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAM135B, not a curated reading list.
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