EIF1AX
EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
Overview
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, somatic mutation 0.74). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Lung, Prostate Adenocarcinoma, Cutaneous Melanoma, Endometrial Carcinoma, Uveal Melanoma, Well-Differentiated Thyroid Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
- 1 · What it is
EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
- 2 · What goes wrong in cancer
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex.
- 3 · How drugs use it
No product in this corpus aims at EIF1AX yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:3250 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P47813 (protein name, function text, keywords and locations (REST API)); CIViC gene EIF1AX (1 evidence items, 0 assertions, 1 variants; diseases: Uveal Melanoma (GraphQL API, CC0)); Open Targets ENSG00000173674 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0)); IntOGen EIF1AX (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Location: Cytoplasm (UniProt). Locus Xp22.12 (HGNC).
- Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)
- Lung cancer: IntOGen driver in 1 cohort (LUNG)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Uveal melanoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (UM)
- Melanoma: IntOGen driver in 1 cohort (SKCM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EIF1AX" OR ABSTRACT:"EIF1AX" OR TITLE:"eukaryotic translation initiation factor 1A X-linked" OR ABSTRACT:"eukaryotic translation initiation factor 1A X-linked" OR TITLE:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR ABSTRACT:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR TITLE:"eIF-1A" OR ABSTRACT:"eIF-1A" OR TITLE:"eIF-4C" OR ABSTRACT:"eIF-4C" OR TITLE:"EIF4C" OR ABSTRACT:"EIF4C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EIF1AX, not a curated reading list.
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