EIF1AX
EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Location: Cytoplasm (UniProt). Locus Xp22.12 (HGNC).
- Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)
- Lung cancer: IntOGen driver in 1 cohort (LUNG)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Uveal melanoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (UM)
- Melanoma: IntOGen driver in 1 cohort (SKCM)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"EIF1AX" OR ABSTRACT:"EIF1AX" OR TITLE:"eukaryotic translation initiation factor 1A X-linked" OR ABSTRACT:"eukaryotic translation initiation factor 1A X-linked" OR TITLE:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR ABSTRACT:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR TITLE:"eIF-1A" OR ABSTRACT:"eIF-1A" OR TITLE:"eIF-4C" OR ABSTRACT:"eIF-4C" OR TITLE:"EIF4C" OR ABSTRACT:"EIF4C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EIF1AX, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/eif1ax.json. Licence CC BY-NC 4.0.