AFF3
AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
Overview
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, animal model 0.46, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Lung Adenocarcinoma, Well-Differentiated Thyroid Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
- 1 · What it is
AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
- 2 · What goes wrong in cancer
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
- 3 · How drugs use it
No product in this corpus aims at AFF3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6473 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51826 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000144218 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: gastric cancer 0.52, skin cancer 0.55, breast cancer 0.58, lung cancer 0.55 (GraphQL API, CC0)); IntOGen AFF3 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. Location: Nucleus (UniProt). Locus 2q11.2 (HGNC).
- Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AFF3" OR ABSTRACT:"AFF3" OR TITLE:"ALF transcription elongation factor 3" OR ABSTRACT:"ALF transcription elongation factor 3" OR TITLE:"AF4/FMR2 family member 3" OR ABSTRACT:"AF4/FMR2 family member 3" OR TITLE:"MLLT2-like" OR ABSTRACT:"MLLT2-like" OR TITLE:"LAF4" OR ABSTRACT:"LAF4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AFF3, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetBARD1
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetCBLB
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetABL2
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetNUP98
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetDROSHA
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetNKX2-1
Shares Thyroid cancer, Lung cancer (all types), Skin cancer (all types), IntOGen.
- TargetACVR1B
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetSMAD3
Shares Thyroid cancer, Lung cancer (all types), Skin cancer (all types), Breast cancer (all types).