COL2A1
COL2A1 (Collagen alpha-1(II) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer and Papillary thyroid cancer.
Overview
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Well-Differentiated Thyroid Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · COL2A1 (Collagen alpha-1(II) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer and Papillary thyroid cancer.
- 1 · What it is
COL2A1 (Collagen alpha-1(II) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer and Papillary thyroid cancer.
- 2 · What goes wrong in cancer
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
- 3 · How drugs use it
No product in this corpus aims at COL2A1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:2200 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02458 (protein name, function text, keywords and locations (REST API)); IntOGen COL2A1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 12q13.11 (HGNC).
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Papillary thyroid cancer: IntOGen driver in 1 cohort (WDTC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"COL2A1" OR ABSTRACT:"COL2A1" OR TITLE:"collagen type II alpha 1 chain" OR ABSTRACT:"collagen type II alpha 1 chain" OR TITLE:"Collagen alpha-1 II chain" OR ABSTRACT:"Collagen alpha-1 II chain" OR TITLE:"STL1" OR ABSTRACT:"STL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about COL2A1, not a curated reading list.
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