ARHGAP5
ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
Overview
GTPase-activating protein for Rho family members.
IntOGen calls it a driver in 7 cohorts (3 activating, 4 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma, Pleural Mesothelioma, Well-Differentiated Thyroid Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
- 1 · What it is
ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
- 2 · What goes wrong in cancer
GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ARHGAP5 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:675 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13017 (protein name, function text, keywords and locations (REST API)); IntOGen ARHGAP5 (driver in 7 cohorts (Act 3, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt). Locus 14q12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 2 cohorts (BLCA)
- Multiple myeloma: IntOGen driver in 2 cohorts (PCM)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ARHGAP5" OR ABSTRACT:"ARHGAP5" OR TITLE:"Rho GTPase activating protein 5" OR ABSTRACT:"Rho GTPase activating protein 5" OR TITLE:"Rho GTPase-activating protein 5" OR ABSTRACT:"Rho GTPase-activating protein 5" OR TITLE:"RhoGAP5" OR ABSTRACT:"RhoGAP5" OR TITLE:"p190-B" OR ABSTRACT:"p190-B" OR TITLE:"p190BRhoGAP" OR ABSTRACT:"p190BRhoGAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGAP5, not a curated reading list.
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