CHD7
CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
Overview
ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
- 1 · What it is
CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
- 2 · What goes wrong in cancer
ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator.
- 3 · How drugs use it
No product in this corpus aims at CHD7 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:20626 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P2D1 (protein name, function text, keywords and locations (REST API)); IntOGen CHD7 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 8q12.2 (HGNC).
- Medulloblastoma: IntOGen driver in 1 cohort (MBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CHD7" OR ABSTRACT:"CHD7" OR TITLE:"chromodomain helicase DNA binding protein 7" OR ABSTRACT:"chromodomain helicase DNA binding protein 7" OR TITLE:"ATP-dependent chromatin remodeler CHD7" OR ABSTRACT:"ATP-dependent chromatin remodeler CHD7" OR TITLE:"KIAA1416" OR ABSTRACT:"KIAA1416" OR TITLE:"FLJ20357" OR ABSTRACT:"FLJ20357" OR TITLE:"FLJ20361" OR ABSTRACT:"FLJ20361") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CHD7, not a curated reading list.
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