KDM3B
KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Overview
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity.
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
- 1 · What it is
KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
- 2 · What goes wrong in cancer
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
- 3 · How drugs use it
No product in this corpus aims at KDM3B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:1337 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7LBC6 (protein name, function text, keywords and locations (REST API)); IntOGen KDM3B (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity. Location: Nucleus (UniProt). Locus 5q31.2 (HGNC).
- Medulloblastoma: IntOGen driver in 1 cohort (MBL)
- Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KDM3B" OR ABSTRACT:"KDM3B" OR TITLE:"lysine demethylase 3B" OR ABSTRACT:"lysine demethylase 3B" OR TITLE:"Lysine-specific demethylase 3B" OR ABSTRACT:"Lysine-specific demethylase 3B" OR TITLE:"KIAA1082" OR ABSTRACT:"KIAA1082" OR TITLE:"NET22" OR ABSTRACT:"NET22" OR TITLE:"C5orf7" OR ABSTRACT:"C5orf7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KDM3B, not a curated reading list.
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