FAM174B
FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
Overview
Essential for Golgi structural integrity.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
- 1 · What it is
FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
- 2 · What goes wrong in cancer
Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FAM174B yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:34339 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q3ZCQ3 (protein name, function text, keywords and locations (REST API)); IntOGen FAM174B (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt). Locus 15q26.1 (HGNC).
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Medulloblastoma: IntOGen driver in 1 cohort (MBL)
- Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FAM174B" OR ABSTRACT:"FAM174B" OR TITLE:"family with sequence similarity 174 member B" OR ABSTRACT:"family with sequence similarity 174 member B" OR TITLE:"Membrane protein FAM174B" OR ABSTRACT:"Membrane protein FAM174B" OR TITLE:"LOC400451" OR ABSTRACT:"LOC400451" OR TITLE:"MGC102891" OR ABSTRACT:"MGC102891") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAM174B, not a curated reading list.
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