TRIM33
TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalling cascade. Plays a role in the control of cell proliferation. Location: Nucleus (UniProt). Locus 1p13.2 (HGNC).
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
- Medulloblastoma: IntOGen driver in 2 cohorts (MBL)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"TRIM33" OR ABSTRACT:"TRIM33" OR TITLE:"tripartite motif containing 33" OR ABSTRACT:"tripartite motif containing 33" OR TITLE:"E3 ubiquitin-protein ligase TRIM33" OR ABSTRACT:"E3 ubiquitin-protein ligase TRIM33" OR TITLE:"TIF1GAMMA" OR ABSTRACT:"TIF1GAMMA" OR TITLE:"FLJ11429" OR ABSTRACT:"FLJ11429" OR TITLE:"KIAA1113" OR ABSTRACT:"KIAA1113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM33, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/trim33.json. Licence CC BY-NC 4.0.