ZNF680
ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
Overview
May be involved in transcriptional regulation.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
- 1 · What it is
ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZNF680 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:26897 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NEM1 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF680 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 7q11.21 (HGNC).
- Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF680" OR ABSTRACT:"ZNF680" OR TITLE:"zinc finger protein 680" OR ABSTRACT:"zinc finger protein 680" OR TITLE:"Zinc finger protein 680" OR ABSTRACT:"Zinc finger protein 680" OR TITLE:"FLJ90430" OR ABSTRACT:"FLJ90430") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF680, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetNUTM2D
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF626
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF721
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF780A
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF90
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF93
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF331
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetDSP
Shares Nasopharyngeal carcinoma, IntOGen.