ZNF331
ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
Overview
May be involved in transcriptional regulation. May play a role in spermatogenesis.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.14, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
- 1 · What it is
ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. May play a role in spermatogenesis.
- 3 · How drugs use it
No product in this corpus aims at ZNF331 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:15489 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQX6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130844 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.51 (GraphQL API, CC0)); IntOGen ZNF331 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be involved in transcriptional regulation. May play a role in spermatogenesis. Location: Nucleus (UniProt). Locus 19q13.42 (HGNC).
- Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF331" OR ABSTRACT:"ZNF331" OR TITLE:"zinc finger protein 331" OR ABSTRACT:"zinc finger protein 331" OR TITLE:"Zinc finger protein 331" OR ABSTRACT:"Zinc finger protein 331" OR TITLE:"ZNF463" OR ABSTRACT:"ZNF463" OR TITLE:"ZNF361" OR ABSTRACT:"ZNF361") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF331, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetKAT6B
Shares Nasopharyngeal carcinoma, Skin cancer (all types), IntOGen, Melanoma.
- TargetNUTM2D
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF626
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF680
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF721
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF780A
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF90
Shares Nasopharyngeal carcinoma, IntOGen.
- TargetZNF93
Shares Nasopharyngeal carcinoma, IntOGen.