PSIP1
PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
Overview
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.25, literature 0.97, genetic association 0.13, somatic mutation 0.87, animal model 0.25). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Gallbladder Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
- 1 · What it is
PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
- 2 · What goes wrong in cancer
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses.
- 3 · How drugs use it
No product in this corpus aims at PSIP1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:9527 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75475 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164985 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.51, urinary bladder cancer 0.51 (GraphQL API, CC0)); IntOGen PSIP1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Location: Nucleus (UniProt). Locus 9p22.3 (HGNC).
- Bladder & urothelial cancer: Open Targets association 0.51 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 1 cohort (BLCA)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Gallbladder cancer: IntOGen driver in 1 cohort (GBC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PSIP1" OR ABSTRACT:"PSIP1" OR TITLE:"PC4 and SRSF1 interacting protein 1" OR ABSTRACT:"PC4 and SRSF1 interacting protein 1" OR TITLE:"PC4 and SFRS1-interacting protein" OR ABSTRACT:"PC4 and SFRS1-interacting protein" OR TITLE:"p52" OR ABSTRACT:"p52" OR TITLE:"LEDGF" OR ABSTRACT:"LEDGF" OR TITLE:"p75" OR ABSTRACT:"p75") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSIP1, not a curated reading list.
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