CASZ1
CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Overview
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 1 · What it is
CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
- 3 · How drugs use it
No product in this corpus aims at CASZ1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:26002 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86V15 (protein name, function text, keywords and locations (REST API)); IntOGen CASZ1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. Location: Nucleus (UniProt). Locus 1p36.22 (HGNC).
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CASZ1" OR ABSTRACT:"CASZ1" OR TITLE:"castor zinc finger 1" OR ABSTRACT:"castor zinc finger 1" OR TITLE:"Zinc finger protein castor homolog 1" OR ABSTRACT:"Zinc finger protein castor homolog 1" OR TITLE:"FLJ20321" OR ABSTRACT:"FLJ20321" OR TITLE:"ZNF693" OR ABSTRACT:"ZNF693" OR TITLE:"castor" OR ABSTRACT:"castor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CASZ1, not a curated reading list.