NACA
NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
Overview
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration.
IntOGen calls it a driver in 4 cohorts (2 activating, 0 loss-of-function), covering Basal Cell Carcinoma, Bladder Urothelial Carcinoma, Melanoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
- 1 · What it is
NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes.
- 3 · How drugs use it
No product in this corpus aims at NACA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:7629 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt E9PAV3 (protein name, function text, keywords and locations (REST API)); IntOGen NACA (driver in 4 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organised assembly of thick and thin filaments of myofibril sarcomeres. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
- Melanoma: IntOGen driver in 2 cohorts (MEL)
- Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NACA" OR ABSTRACT:"NACA" OR TITLE:"nascent polypeptide associated complex subunit alpha" OR ABSTRACT:"nascent polypeptide associated complex subunit alpha" OR TITLE:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR ABSTRACT:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR TITLE:"NACA1" OR ABSTRACT:"NACA1" OR TITLE:"Alpha-NAC" OR ABSTRACT:"Alpha-NAC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NACA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCPEB3
Shares Basal cell carcinoma, IntOGen.
- TargetPPP6C
Shares Basal cell carcinoma, IntOGen, Melanoma.
- TargetPTPN14
Shares Basal cell carcinoma, IntOGen.
- PersonSusana Puig
Shares Basal cell carcinoma, Melanoma.
- TargetOCA2
Shares Basal cell carcinoma, Melanoma.
- TargetSLC45A2
Shares Basal cell carcinoma, Melanoma.
- TargetTYR
Shares Basal cell carcinoma, Melanoma.
- TargetARHGEF10L
Shares Basal cell carcinoma, IntOGen.