SLC45A2
SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
Overview
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.90, animal model 0.47, genetic association 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
- 1 · What it is
SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Proton-associated glucose and sucrose transporter. May be able to transport also fructose.
- 3 · How drugs use it
No product in this corpus aims at SLC45A2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16472 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UMX9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164175 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.59, basal cell carcinoma 0.51 (GraphQL API, CC0))
Biology
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralisation that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. Location: Melanosome membrane (UniProt). Locus 5p13.2 (HGNC).
- Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
- Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC45A2" OR ABSTRACT:"SLC45A2" OR TITLE:"solute carrier family 45 member 2" OR ABSTRACT:"solute carrier family 45 member 2" OR TITLE:"Membrane-associated transporter protein" OR ABSTRACT:"Membrane-associated transporter protein" OR TITLE:"AIM-1" OR ABSTRACT:"AIM-1" OR TITLE:"OCA4" OR ABSTRACT:"OCA4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC45A2, not a curated reading list.
Similar pages
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