XPA
XPA (DNA repair protein complementing XP-A cells) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer and Basal cell carcinoma.
Overview
Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.94, animal model 0.26, genetic association 0.83, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · XPA (DNA repair protein complementing XP-A cells) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer and Basal cell carcinoma.
- 1 · What it is
XPA (DNA repair protein complementing XP-A cells) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.
- 3 · How drugs use it
No product in this corpus aims at XPA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12814 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23025 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136936 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: colorectal cancer 0.51, skin cancer 0.62, basal cell carcinoma 0.59 (GraphQL API, CC0))
Biology
Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3. Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilising the complex in a different conformation than in transcribing TFIIH. Location: Nucleus (UniProt). Locus 9q22.33 (HGNC).
- Skin cancer: Open Targets association 0.62 with skin cancer (MONDO_0002898)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Basal cell carcinoma: Open Targets association 0.59 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"XPA" OR ABSTRACT:"XPA" OR TITLE:"XPA, DNA damage recognition and repair factor" OR ABSTRACT:"XPA, DNA damage recognition and repair factor" OR TITLE:"DNA repair protein complementing XP-A cells" OR ABSTRACT:"DNA repair protein complementing XP-A cells" OR TITLE:"XP1" OR ABSTRACT:"XP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about XPA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetBNC2
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetCPVL
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetCTSS
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetKRT5
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetTGM3
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetOCA2
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetSLC45A2
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
- TargetTYR
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.