CPVL
CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Overview
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.86, animal model 0.57, genetic association 0.75).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 1 · What it is
CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at CPVL yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:14399 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H3G5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000106066 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: skin cancer 0.57, basal cell carcinoma 0.55 (GraphQL API, CC0))
Biology
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).
- Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)
- Basal cell carcinoma: Open Targets association 0.55 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CPVL" OR ABSTRACT:"CPVL" OR TITLE:"carboxypeptidase vitellogenic like" OR ABSTRACT:"carboxypeptidase vitellogenic like" OR TITLE:"Probable serine carboxypeptidase CPVL" OR ABSTRACT:"Probable serine carboxypeptidase CPVL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CPVL, not a curated reading list.
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