BNC2
BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Overview
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.87, animal model 0.45, genetic association 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 1 · What it is
BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.
- 3 · How drugs use it
No product in this corpus aims at BNC2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:30988 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZN30 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000173068 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: skin cancer 0.52, basal cell carcinoma 0.53 (GraphQL API, CC0))
Biology
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development. Location: Nucleus (UniProt). Locus 9p22.3-p22.2 (HGNC).
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BNC2" OR ABSTRACT:"BNC2" OR TITLE:"basonuclin zinc finger protein 2" OR ABSTRACT:"basonuclin zinc finger protein 2" OR TITLE:"Zinc finger protein basonuclin-2" OR ABSTRACT:"Zinc finger protein basonuclin-2" OR TITLE:"BSN2" OR ABSTRACT:"BSN2" OR TITLE:"FLJ20043" OR ABSTRACT:"FLJ20043" OR TITLE:"bn2" OR ABSTRACT:"bn2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BNC2, not a curated reading list.
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