BACH2
BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
Overview
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.86, animal model 0.49, genetic association 0.72).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
- 1 · What it is
BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE).
- 3 · How drugs use it
No product in this corpus aims at BACH2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:14078 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BYV9 (protein name, function text, keywords and locations (REST API)); CIViC gene BACH2 (2 evidence items, 0 assertions, 2 variants; diseases: (GraphQL API, CC0)); Open Targets ENSG00000112182 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: skin cancer 0.55, basal cell carcinoma 0.53 (GraphQL API, CC0))
Biology
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation. Location: Cytoplasm; Nucleus (UniProt). Locus 6q15 (HGNC).
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BACH2" OR ABSTRACT:"BACH2" OR TITLE:"BACH transcriptional regulator 2" OR ABSTRACT:"BACH transcriptional regulator 2" OR TITLE:"Transcription regulator protein BACH2" OR ABSTRACT:"Transcription regulator protein BACH2" OR TITLE:"BTBD25" OR ABSTRACT:"BTBD25") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BACH2, not a curated reading list.
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