KRT5
KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Overview
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localisation in keratinocytes.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.98, animal model 0.42, genetic association 0.73).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 1 · What it is
KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia.
- 3 · How drugs use it
No product in this corpus aims at KRT5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6442 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P13647 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186081 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: skin cancer 0.56, basal cell carcinoma 0.56 (GraphQL API, CC0))
Biology
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localisation in keratinocytes. Location: Cytoplasm (UniProt). Locus 12q13.13 (HGNC).
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Basal cell carcinoma: Open Targets association 0.56 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KRT5" OR ABSTRACT:"KRT5" OR TITLE:"keratin 5" OR ABSTRACT:"keratin 5" OR TITLE:"Keratin, type II cytoskeletal 5" OR ABSTRACT:"Keratin, type II cytoskeletal 5" OR TITLE:"KRT5A" OR ABSTRACT:"KRT5A" OR TITLE:"CK-5" OR ABSTRACT:"CK-5" OR TITLE:"EBS2" OR ABSTRACT:"EBS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KRT5, not a curated reading list.
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