RNASET2
RNASET2 (Ribonuclease T2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
Overview
Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RNASET2 (Ribonuclease T2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
- 1 · What it is
RNASET2 (Ribonuclease T2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
- 2 · What goes wrong in cancer
Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8.
- 3 · How drugs use it
No product in this corpus aims at RNASET2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:21686 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00584 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000026297 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: basal cell carcinoma 0.53 (GraphQL API, CC0))
Biology
Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. Location: Secreted; Lysosome lumen; Endoplasmic reticulum lumen; Mitochondrion intermembrane space (UniProt). Locus 6q27 (HGNC).
- Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RNASET2" OR ABSTRACT:"RNASET2" OR TITLE:"ribonuclease T2" OR ABSTRACT:"ribonuclease T2" OR TITLE:"Ribonuclease T2" OR ABSTRACT:"Ribonuclease T2" OR TITLE:"RNASE6PL" OR ABSTRACT:"RNASE6PL" OR TITLE:"FLJ10907" OR ABSTRACT:"FLJ10907" OR TITLE:"bA514O12.3" OR ABSTRACT:"bA514O12.3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNASET2, not a curated reading list.