TNS3
TNS3 (Tensin-3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Basal cell carcinoma.
Overview
May act as a protein phosphatase and/or a lipid phosphatase. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.80, animal model 0.31, genetic association 0.72).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TNS3 (Tensin-3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Basal cell carcinoma.
- 1 · What it is
TNS3 (Tensin-3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Basal cell carcinoma.
- 2 · What goes wrong in cancer
May act as a protein phosphatase and/or a lipid phosphatase. Involved in the dissociation of the integrin-tensin-actin complex.
- 3 · How drugs use it
No product in this corpus aims at TNS3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:21616 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q68CZ2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136205 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.52, basal cell carcinoma 0.51 (GraphQL API, CC0))
Biology
May act as a protein phosphatase and/or a lipid phosphatase. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organisation. Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Location: Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7p12.3 (HGNC).
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)
- Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TNS3" OR ABSTRACT:"TNS3" OR TITLE:"tensin 3" OR ABSTRACT:"tensin 3" OR TITLE:"Tensin-3" OR ABSTRACT:"Tensin-3" OR TITLE:"TEM6" OR ABSTRACT:"TEM6" OR TITLE:"H_NH0549I23.2" OR ABSTRACT:"H_NH0549I23.2" OR TITLE:"FLJ13732" OR ABSTRACT:"FLJ13732") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNS3, not a curated reading list.