ZBTB10
ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
Overview
May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, animal model 0.52, genetic association 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
- 1 · What it is
ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZBTB10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:30953 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DT7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205189 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: basal cell carcinoma 0.51 (GraphQL API, CC0))
Biology
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
- Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZBTB10" OR ABSTRACT:"ZBTB10" OR TITLE:"zinc finger and BTB domain containing 10" OR ABSTRACT:"zinc finger and BTB domain containing 10" OR TITLE:"Zinc finger and BTB domain-containing protein 10" OR ABSTRACT:"Zinc finger and BTB domain-containing protein 10" OR TITLE:"RINZF" OR ABSTRACT:"RINZF" OR TITLE:"FLJ12752" OR ABSTRACT:"FLJ12752") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZBTB10, not a curated reading list.